![]() ![]() In addition, when Testolone is compared to RAD 150, RAD 150 is comparable to other esterified SARMs with an increase in half-life and bioavailability. This indicates that additional potential benefits are added by esterification of RAD 140. With increased bioavailability, the compound is absorbed much faster, and with an increased half-life, the compound is active for much longer than RAD 140, the non-esterified compound. ![]() In addition, in a similar way to other esterified SARMs, the bioavailability and half-life of RAD 150 are increased. Due to the addition of the benzoate ester group, the compound now has an increased alkalinity, indicating that the esterified compound is more stable than testolone. During the substitution reaction, a group of benzoate esters is added to Testolone to change the compound into its esterified version, which explains the main structural difference between the two compounds. To synthesize RAD 150 from Testolone, it must undergo the process of esterification. Adding the group of benzoate esters increases the alkalinity of the compound, making it more stable than RAD 140. The main structural difference between the two compounds is the group of benzoate esters that were added during the substitution reaction of esterification. RAD 150 is the esterified version of RAD 140. In some cases, various other strong acids such as hydrochloric acid will be used to catalyze the substitution reaction ( ). Esterification occurs when the carboxylic acid is exposed to heat and a strong acid, normally sulfuric acid. The hydroxyl group (-OH) of the carboxylic acid has been replaced by an alkyl group (-O-). The specific substitution reaction that occurs when a compound becomes an ester is derived from a carboxylic acid. Through the use of DEXA scans, it was discovered that the weight gain was mainly lean muscle mass.Įsterification occurs when a substitution reaction takes place. In addition to providing neuroprotection, testing RAD 140 in young monkeys over a 28-day period was found to result in an average 10% increase in body weight. In addition, the study found that treatment with RAD 140 was actually just as effective in protecting against cell death as treatment with testosterone ( ). Al concluded that RAD 140 supplementation had neuroprotective effects on the brain via MAPK signaling in male rats. Overall, the fascinating study conducted by Jayaramen et. RAD-140 has been most thoroughly studied in male gonadectomized rats suffering from neurodegenerative decline due to decreased androgen levels. RAD 150, also known as TLB 150, is the esterified version of the popular RAD-140 sarm. ![]()
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